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Web a tattoo is a body modification where a person uses a needle to inject dye, ink, or pigment into the skin’s dermis. Web symptoms of an allergic reaction from tattoos can include a red rash, hives, and severe itchiness. Web tattoos breach the skin, which means that skin infections and other complications are possible, including:. Web “if your body tolerates a tattoo at all, it means that the immune system adapted,” says maría daniela hermida, a. Web indeed, some studies have found that tattoo ink creates a sort of priming effect for your immune system,.